Symptoms of thalassemia may include one or more of the following: Paleness. Some people have little or even no symptoms. What if one parent has alpha thalassemia trait and the other parent is a silent carrier? Alpha-gene triplication is a common co-factor that may convert a thalassemia trait to a disease or worsen a benign mutation. If it does, it causes minor anemia. A person may have either alpha thalassemia trait or beta thalassemia trait, depending upon which form of … Intermediate forms of thalassemia can cause mild to moderate anemia and may be associated with other health problems such as slowed growth, delayed puberty, bone … It leads to a decrease in overall hemoglobin levels, with the characteristic signs and symptoms of anemia.. Signs and symptoms of alpha thalassemia are those of other types of anemia and include. What are the Symptoms of Thalassemia? Thalassemia minor generally doesn’t cause any symptoms. This is why it is also sometimes referred to as Mediterranean anemia. For example, people affected by milder forms of thalassemia can develop mild anemia or may have no signs or symptoms of the condition at all. Learn more about thalassemia, also known as Mediterranean Anemia, Cooley's Anemia or Homozygous Beta Thalassemia, and possible signs, symptoms, and treatment options for both thalassemia trait and tha Some such cases result from an autosomal dominant form of thalassemia and others from inheriting a mutation that is not detected by the probes utilized in the DNA testing. A person may have alpha or beta thalassemia, and symptoms … For moderate to severe thalassemia, treatments might include: Frequent blood transfusions. Alpha Thalassemia Minor, also called Alpha Thalassemia Trait (2 genes affected). Tiredness, low energy, or muscle weakness (also called fatigue). Some babies show signs and symptoms of thalassemia at birth, while others may develop them during the first two years of life. Thalassemia is an inherited blood disorder. More severe forms of thalassemia often require frequent blood transfusions, possibly every few weeks. Hemoglobin E/thalassemia: common in Cambodia, Thailand, and parts of India, it is clinically similar to β thalassemia major or thalassemia intermedia. It inhibits the production of hemoglobin and red blood cells. People who have alpha thalassemia trait have red blood cells that are smaller (microcytic) and paler (hypochromic) than normal, have a decreased MCV (mean corpuscular volume, a measurement of the average size of a single red blood cell), and have a mild chronic anemia. Symptoms of thalassemia. Thalassemia symptoms depend on the type of thalassemia you have and the severity of the anemia. General Symptoms of Thalassemia. There are two subtypes of the disorder (alpha and beta) depending on what portion of the hemoglobin is abnormally synthesized. Other people have mild to severe symptoms. Beta Thalassemia trait: Thalassemia is an inherited blood disorder characterized by abnormal synthesis of hemoglobin. The signs and symptoms you experience depend on the type and severity of your condition. Beta Thalassemia trait: Introduction. If one parent has the cis form of alpha thalassemia trait (αα/--), and the other parent is a silent carrier (αα/α-), there is a 25 percent (1 in 4) chance with each pregnancy of having a child with hemoglobin H disease. Your symptoms will depend on the category of thalassemia you have. Alpha thalassemia is an inherited blood disorder that affects the way hemoglobin (the molecule that carries iron and oxygen in the blood) is produced. 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